NS-2664

NS-2664

Identifiers
IUPAC name 5-furan-3-yl-1-(3-imidazol-1-yl-phenyl)-1H-benzoimidazole
PubChem (CID)	9840300
ChemSpider	8016018
Chemical and physical data
Formula	C20H14N4O
Molar mass	326.351 g/mol
3D model (Jmol)	Interactive image
SMILES c5occc5-c(cc1nc4)ccc1n4-c2cc(ccc2)-n3cncc3
InChI InChI=1S/C20H14N4O/c1-2-17(23-8-7-21-13-23)11-18(3-1)24-14-22-19-10-15(4-5-20(19)24)16-6-9-25-12-16/h1-14H Key:QMKRPSVBKKEAKS-UHFFFAOYSA-N
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NS-2664 (LS-193,048) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company Neurosearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2664 is a potent but non-selective partial agonist at GABA_A receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has potent anticonvulsant effects in animal studies, but a relatively short duration of action, and produces little sedative effects or physical dependence.^[1]

References

1. Mirza NR, Nielsen EØ. Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice? Journal of Pharmacology and Experimental Therapeutics. 2006 Mar;316(3):1378-85. PMID 16352707