Benzobarbital

Benzobarbital

Clinical data
ATC code	none
Identifiers
IUPAC name 1-benzoyl-5-ethyl-5-phenyl-1,3-diazinane-2,4,6-trione
Synonyms	Benzonal
CAS Number	744-80-9
PubChem (CID)	12938
ChemSpider	12402
UNII	YNJ78BD0AH
ChEMBL	CHEMBL1338506
Chemical and physical data
Formula	C19H16N2O4
Molar mass	336.341 g/mol
3D model (Jmol)	Interactive image
SMILES CCC1(C(=O)NC(=O)N(C1=O)C(=O)C2=CC=CC=C2)C3=CC=CC=C3
InChI InChI=1S/C19H16N2O4/c1-2-19(14-11-7-4-8-12-14)16(23)20-18(25)21(17(19)24)15(22)13-9-5-3-6-10-13/h3-12H,2H2,1H3,(H,20,23,25) Key:QMOWPJIFTHVQMB-UHFFFAOYSA-N
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Benzobarbital (Benzonal) is a barbiturate derivative. It has anticonvulsant effects and has been used for the treatment of epilepsy. ^[1]

It has similar liver enzyme inducing effects to the closely related drug phenobarbital, which may be exploited in some clinical applications. ^{[2] [3]}

References

1. Okudzhava, V. M.; Chankvetadze, B. G. (1989). "Pharmacological characteristics of an anti-convulsive drug Benzonal and the evaluation of its therapeutic effectiveness (literature review)". Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (in Russian). Moscow. 89 (11): 136–145. ISSN 0044-4588. PMID 2696306.
2. Nadzhimutdinov, K. N.; Khakimov, Z. Z.; Kabulov, Sh. M. (1992). "The advantages of benzonal as an inducer of the liver mono-oxygenase enzyme system compared to phenobarbital". Eksperimental'naia i klinicheskaia farmakologiia (in Russian). Moscow. 55 (1): 68–71. ISSN 0869-2092. PMID 1305441.
3. Novozheeva, T. P.; Saratikov, A. S.; Grishanova, A. U.; Gutkina, N. I.; Akhmedzhanov, R. R.; Khatsenko, O. G.; Kozlovskaia, N. E. (1991). "Benzonal--a phenobarbital-type of inducer of the mono-oxygenase system". Biulleten' eksperimental'noi biologii i meditsiny (in Russian). Moscow. 111 (2): 163–165. ISSN 0365-9615. OCLC 613807502. PMID 1854958.