IGSF8

IGSF8
Identifiers
Aliases	IGSF8, CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, immunoglobulin superfamily member 8
External IDs	MGI: 2154090 HomoloGene: 14163 GeneCards: IGSF8
Gene ontology Molecular function • protein binding Cellular component • extracellular exosome • membrane • integral component of membrane • plasma membrane Biological process • skeletal muscle tissue development • nervous system development • cell proliferation • single fertilization • movement of cell or subcellular component Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	93185	140559
Ensembl	ENSG00000162729	ENSMUSG00000038034
UniProt	Q969P0	Q8R366
RefSeq (mRNA)	NM_001206665 NM_052868 NM_001320247	NM_080419
RefSeq (protein)	NP_001193594.1 NP_443100.1 NP_001307176.1	NP_536344.1
Location (UCSC)	Chr 1: 160.09 – 160.1 Mb	Chr 1: 172.26 – 172.32 Mb
PubMed search	[1]	[2]
Wikidata

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Immunoglobulin superfamily member 8 is a protein that in humans is encoded by the IGSF8 gene.^[3][4][5] IGSF8 has also been designated as CD316 (cluster of differentiation 316).

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Stipp CS, Kolesnikova TV, Hemler ME (Oct 2001). "EWI-2 is a major CD9 and CD81 partner and member of a novel Ig protein subfamily". J Biol Chem. 276 (44): 40545–54. doi:10.1074/jbc.M107338200. PMID 11504738.
4. Clark KL, Zeng Z, Langford AL, Bowen SM, Todd SC (Oct 2001). "PGRL is a major CD81-associated protein on lymphocytes and distinguishes a new family of cell surface proteins". J Immunol. 167 (9): 5115–21. doi:10.4049/jimmunol.167.9.5115. PMID 11673522.
5. "Entrez Gene: IGSF8 immunoglobulin superfamily, member 8".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Charrin S, Le Naour F, Labas V, et al. (2003). "EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells.". Biochem. J. 373 (Pt 2): 409–21. doi:10.1042/BJ20030343. PMC 1223506. PMID 12708969.
• Zhang XA, Lane WS, Charrin S, et al. (2003). "EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells.". Cancer Res. 63 (10): 2665–74. PMID 12750295.
• Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes.". Br. J. Dermatol. 148 (4): 654–64. doi:10.1046/j.1365-2133.2003.05244.x. PMID 12752121.
• Stipp CS, Kolesnikova TV, Hemler ME (2004). "EWI-2 regulates alpha3beta1 integrin-dependent cell functions on laminin-5.". J. Cell Biol. 163 (5): 1167–77. doi:10.1083/jcb.200309113. PMC 2173626. PMID 14662754.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kolesnikova TV, Stipp CS, Rao RM, et al. (2004). "EWI-2 modulates lymphocyte integrin alpha4beta1 functions.". Blood. 103 (8): 3013–9. doi:10.1182/blood-2003-07-2201. PMID 15070678.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yang XH, Kovalenko OV, Kolesnikova TV, et al. (2006). "Contrasting effects of EWI proteins, integrins, and protein palmitoylation on cell surface CD9 organization.". J. Biol. Chem. 281 (18): 12976–85. doi:10.1074/jbc.M510617200. PMID 16537545.
• Sala-Valdés M, Ursa A, Charrin S, et al. (2006). "EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins.". J. Biol. Chem. 281 (28): 19665–75. doi:10.1074/jbc.M602116200. PMID 16690612.
• Kettner S, Kalthoff F, Graf P, et al. (2007). "EWI-2/CD316 is an inducible receptor of HSPA8 on human dendritic cells.". Mol. Cell. Biol. 27 (21): 7718–26. doi:10.1128/MCB.00180-07. PMC 2169036. PMID 17785435.

External links

• IGSF8 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)