Etazocine

Etazocine

Clinical data
ATC code	None
Legal status
Legal status	Non-regulated
Identifiers
IUPAC name 1,2,3,4,5,6-hexahydro-6,11-diethyl-3-methyl-2,6-methano-3-benzazocin-8-ol or 5,7-diethyl-2-hydroxy-2-methyl-6,7-benzomorphan
Synonyms	NIH-7856 ((±)-form); GPA-208 ((−)-form); GPA-2087 ((−)-form); NIH-8178 ((−)-form); FDA-0487 ((−)-form)
CAS Number	34254-87-0 10286-45-0 ((−)-form (HCl))
PubChem (CID)	187767
ChemSpider	163214
Chemical and physical data
Formula	C17H25NO
Molar mass	259.387 g/mol
3D model (Jmol)	Interactive image
SMILES Oc1ccc3c(c1)[C@@]2([C@H]([C@@H](N(CC2)C)C3)CC)CC
InChI InChI=1S/C17H25NO/c1-4-14-16-10-12-6-7-13(19)11-15(12)17(14,5-2)8-9-18(16)3/h6-7,11,14,16,19H,4-5,8-10H2,1-3H3/t14-,16-,17-/m0/s1 Key:JYRBQCWXZNDERM-XIRDDKMYSA-N

Etazocine (NIH-7856) is an opioid analgesic of the benzomorphan family which was never marketed.^[1][2] It acts as a partial agonist of the opioid receptors, with mixed agonist and antagonist effects.^[1] In animal studies, it was shown to induce analgesia, dependency, and respiratory depression, with overall effects similar to those of morphine, but with substantially reduced potency in comparison.^[1][2][3]

See also

• Benzomorphan

References

1. National Research Council (U.S.). Committee on Problems of Drug Dependence, American Medical Association. Committee on Alcoholism and Drug Dependence, American Medical Association. Council on Mental Health, National Academy of Sciences (U.S.) (1969). Bulletin, problems of drug dependence. National Academies. pp. 5820–5821. NAP:10503. Retrieved 22 April 2012.
2. Smethurst PW, Forrest WH, Hayden J (December 1971). "The respiratory effects of a potent analgesic (GPA 2087) in man". British Journal of Anaesthesia. 43 (12): 1129–35. doi:10.1093/bja/43.12.1129. PMID 5156297.
3. National Research Council (U.S.). Committee on Problems of Drug Dependence (1970). Report of the annual scientific meeting. National Research Council. Retrieved 22 April 2012.