TLR6

TLR6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OM7
Identifiers
Aliases	TLR6, CD286, toll like receptor 6
External IDs	OMIM: 605403 MGI: 1341296 HomoloGene: 21223 GeneCards: TLR6
Gene ontology Molecular function • Toll-like receptor 2 binding • protein binding • receptor activity • transmembrane signaling receptor activity • lipopeptide binding Cellular component • integral component of membrane • phagocytic vesicle membrane • membrane • integral component of plasma membrane • cytoplasmic vesicle • Golgi apparatus • membrane raft • Toll-like receptor 2-Toll-like receptor 6 protein complex • plasma membrane Biological process • positive regulation of NLRP3 inflammasome complex assembly • immune system process • positive regulation of JUN kinase activity • regulation of cytokine secretion • cellular response to diacyl bacterial lipopeptide • activation of NF-kappaB-inducing kinase activity • toll-like receptor 6 signaling pathway • interleukin-1 beta secretion • defense response to bacterium • positive regulation of I-kappaB kinase/NF-kappaB signaling • inflammatory response • toll-like receptor TLR6:TLR2 signaling pathway • positive regulation of interleukin-6 biosynthetic process • toll-like receptor signaling pathway • detection of diacyl bacterial lipopeptide • signal transduction • immune response • innate immune response • T-helper 1 type immune response • MyD88-dependent toll-like receptor signaling pathway • nitric oxide metabolic process • response to bacterial lipoprotein • microglial cell activation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10333	21899
Ensembl	ENSG00000174130	ENSMUSG00000051498
UniProt	Q9Y2C9	Q9EPW9
RefSeq (mRNA)	NM_006068	NM_011604
RefSeq (protein)	NP_006059.2	NP_035734.3
Location (UCSC)	Chr 4: 38.82 – 38.86 Mb	Chr 5: 64.95 – 64.96 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Toll-like receptor 6 is a protein that in humans is encoded by the TLR6 gene.^[3] TLR6 has also been designated as CD286 (cluster of differentiation 286).

The protein encoded by this gene is a member of the toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize microbe-associated molecular patterns (MAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Takeuchi O, Kawai T, Sanjo H, Copeland NG, Gilbert DJ, Jenkins NA, Takeda K, Akira S (Jun 1999). "TLR6: A novel member of an expanding toll-like receptor family". Gene. 231 (1–2): 59–65. doi:10.1016/S0378-1119(99)00098-0. PMID 10231569.
4. "Entrez Gene: TLR6 toll-like receptor 6".

Further reading

• Lien E, Ingalls RR (2002). "Toll-like receptors". Crit. Care Med. 30 (1 Suppl): S1–11. doi:10.1097/00003246-200201001-00001. PMID 11782555.

External links

• Toll-Like Receptor 6 at the US National Library of Medicine Medical Subject Headings (MeSH)
• TLR6 human gene location in the UCSC Genome Browser.
• TLR6 human gene details in the UCSC Genome Browser.