Interleukin 1 receptor, type II

IL1R2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3O4O
Identifiers
Aliases	IL1R2, CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB, Interleukin 1 receptor, type II, interleukin 1 receptor type 2
External IDs	MGI: 96546 HomoloGene: 7783 GeneCards: IL1R2
Gene ontology Molecular function • interleukin-1, Type II, blocking receptor activity • protein binding • interleukin-1 receptor activity • interleukin-1 binding Cellular component • integral component of membrane • extracellular region • plasma membrane • membrane • cytoplasm Biological process • immune response • cytokine-mediated signaling pathway • negative regulation of protein processing • negative regulation of cytokine production involved in inflammatory response • negative regulation of interleukin-1-mediated signaling pathway • negative regulation of interleukin-1 alpha secretion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7850	16178
Ensembl	ENSG00000115590	ENSMUSG00000026073
UniProt	P27930	P27931
RefSeq (mRNA)	NM_001261419 NM_004633 NM_173343	NM_010555
RefSeq (protein)	NP_001248348.1 NP_004624.1	NP_034685.1
Location (UCSC)	Chr 2: 101.99 – 102.03 Mb	Chr 1: 40.07 – 40.13 Mb
PubMed search	[1]	[2]
Wikidata

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Interleukin 1 receptor, type II (IL-1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.

Function

The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. IL-1R2 protein also interacts non-productively with the second component of the signalling IL-1 receptor, namely IL-1RAcP,^[3] and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography.^[4] Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.^[5]

See also

• Cluster of differentiation
• Interleukin 1 receptor, type I

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Lang, D; Knop, J; Wesche, H; Raffetseder, U; Kurrie, R; Boraschi, D; Martin, MU (1998). "The type II IL-1 receptor interacts with the IL-1 receptor accessory protein: a novel mechanism of regulation of IL-1 responsiveness.". Journal of Immunology. 161 (12): 6871–6877.
4. Wang, Dongli; Zhang, Senyan; Li, Liang; Liu, Xi; Mei, Kunrong; Wang, Xinquan (29 August 2010). "Structural insights into the assembly and activation of IL-1β with its receptors". Nature Immunology. 11 (10): 905–911. doi:10.1038/ni.1925.
5. "Entrez Gene: IL1R2 interleukin 1 receptor, type II".

Further reading

• McMahan CJ, Slack JL, Mosley B, Cosman D, Lupton SD, Brunton LL, Grubin CE, Wignall JM, Jenkins NA, Brannan CI (Oct 1991). "A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types". The EMBO Journal. 10 (10): 2821–32. PMC 452992. PMID 1833184.
• Dripps DJ, Verderber E, Ng RK, Thompson RC, Eisenberg SP (Oct 1991). "Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils". The Journal of Biological Chemistry. 266 (30): 20311–5. PMID 1834644.
• Fasano MB, Cousart S, Neal S, McCall CE (Nov 1991). "Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome". The Journal of Clinical Investigation. 88 (5): 1452–9. doi:10.1172/JCI115454. PMC 295647. PMID 1834697.
• Sadouk MB, Pelletier JP, Tardif G, Kiansa K, Cloutier JM, Martel-Pelletier J (Sep 1995). "Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor". Laboratory Investigation. 73 (3): 347–55. PMID 7564267.
• Symons JA, Young PR, Duff GW (Feb 1995). "Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist". Proceedings of the National Academy of Sciences of the United States of America. 92 (5): 1714–8. doi:10.1073/pnas.92.5.1714. PMC 42590. PMID 7878046.
• Arend WP, Malyak M, Smith MF, Whisenand TD, Slack JL, Sims JE, Giri JG, Dower SK (Nov 1994). "Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids". Journal of Immunology. 153 (10): 4766–74. PMID 7963543.
• Giri JG, Wells J, Dower SK, McCall CE, Guzman RN, Slack J, Bird TA, Shanebeck K, Grabstein KH, Sims JE (Dec 1994). "Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses". Journal of Immunology. 153 (12): 5802–9. PMID 7989776.
• Re F, Muzio M, De Rossi M, Polentarutti N, Giri JG, Mantovani A, Colotta F (Feb 1994). "The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor". The Journal of Experimental Medicine. 179 (2): 739–43. doi:10.1084/jem.179.2.739. PMC 2191363. PMID 8294881.
• Colotta F, Re F, Muzio M, Bertini R, Polentarutti N, Sironi M, Giri JG, Dower SK, Sims JE, Mantovani A (Jul 1993). "Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4". Science. 261 (5120): 472–5. doi:10.1126/science.8332913. PMID 8332913.
• Sambo P, Fadlon EJ, Sironi M, Matteucci C, Introna M, Mantovani A, Colotta F (Mar 1996). "Reactive oxygen intermediates cause rapid release of the interleukin-1 decoy receptor from human myelomonocytic cells". Blood. 87 (5): 1682–6. PMID 8634411.
• Larregina A, Morelli A, Kolkowski E, Fainboim L (Feb 1996). "Flow cytometric analysis of cytokine receptors on human Langerhans' cells. Changes observed after short-term culture". Immunology. 87 (2): 317–25. doi:10.1046/j.1365-2567.1996.451513.x. PMC 1384291. PMID 8698397.
• Liu C, Hart RP, Liu XJ, Clevenger W, Maki RA, De Souza EB (Aug 1996). "Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA". The Journal of Biological Chemistry. 271 (34): 20965–72. doi:10.1074/jbc.271.34.20965. PMID 8702856.
• Colotta F, Saccani S, Giri JG, Dower SK, Sims JE, Introna M, Mantovani A (Apr 1996). "Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes". Journal of Immunology. 156 (7): 2534–41. PMID 8786316.
• Sébire G, Delfraissy JF, Demotes-Mainard J, Oteifeh A, Emilie D, Tardieu M (Aug 1996). "Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells". Cytokine. 8 (8): 636–41. doi:10.1006/cyto.1996.0085. PMID 8894439.
• Lovenberg TW, Crowe PD, Liu C, Chalmers DT, Liu XJ, Liaw C, Clevenger W, Oltersdorf T, De Souza EB, Maki RA (Nov 1996). "Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2)". Journal of Neuroimmunology. 70 (2): 113–22. doi:10.1016/S0165-5728(96)00047-1. PMID 8898719.
• van der Poll T, de Waal Malefyt R, Coyle SM, Lowry SF (Jan 1997). "Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13". The Journal of Infectious Diseases. 175 (1): 118–22. doi:10.1093/infdis/175.1.118. PMID 8985204.
• Rauschmayr T, Groves RW, Kupper TS (May 1997). "Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation". Proceedings of the National Academy of Sciences of the United States of America. 94 (11): 5814–9. doi:10.1073/pnas.94.11.5814. PMC 20863. PMID 9159157.
• Gomez E, Morel G, Cavalier A, Liénard MO, Haour F, Courtens JL, Jégou B (Jun 1997). "Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes". Biology of Reproduction. 56 (6): 1513–26. doi:10.1095/biolreprod56.6.1513. PMID 9166705.
• Cannon JG, Angel JB, Abad LW, Vannier E, Mileno MD, Fagioli L, Wolff SM, Komaroff AL (May 1997). "Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome". Journal of Clinical Immunology. 17 (3): 253–61. doi:10.1023/A:1027314713231. PMID 9168406.
• Fink GW, Norman JG (Dec 1997). "Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis". Cytokine. 9 (12): 1023–7. doi:10.1006/cyto.1997.0260. PMID 9417814.

External links

• IL1R2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.