ATF7

ATF7
Identifiers
Aliases	ATF7, ATFA, activating transcription factor 7
External IDs	MGI: 2443472 HomoloGene: 4994 GeneCards: ATF7
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • enzyme binding • sequence-specific DNA binding • DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • protein binding • metal ion binding • mitogen-activated protein kinase binding • nucleic acid binding Cellular component • cytoplasm • nuclear periphery • nucleus • nucleoplasm Biological process • viral process • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11016	223922
Ensembl	ENSG00000170653	ENSMUSG00000099083
UniProt	P17544	Q8R0S1
RefSeq (mRNA)	NM_001130059 NM_001130060 NM_001206682 NM_001206683 NM_006856	NM_146065 NM_001310066 NM_001310067 NM_001310070
RefSeq (protein)	NP_001123532.1 NP_001193611.1 NP_001193612.1 NP_006847.1	n/a
Location (UCSC)	Chr 12: 53.51 – 53.63 Mb	Chr 15: 102.53 – 102.63 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ATF7 gene.^[3][4][5]

Homonym

In 2001, Peters et al. published a paper showing that ATF-7, a Novel bZIP Protein, interacts with PTP4A1.^[4] This ATF-7 is actually ATF5 and not ATF7, as noted by the authors at the end of their paper ("Note Added in Proof—While this manuscript was under review, sequences for mouse and human ATF-5 were deposited in GenBankTM. It appears that ATF-7 and ATF-5 are likely to be the same protein. In addition, an unrelated sequence named ATF7 has also been deposited in GenBankTM. In order to avoid confusion, future work on the protein described in this publication will likely refer to it as either ATF-5 or ATF-5/7.")^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Gaire M, Chatton B, Kedinger C (Aug 1990). "Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells". Nucleic Acids Res. 18 (12): 3467–73. doi:10.1093/nar/18.12.3467. PMC 330998. PMID 1694576.
4. Peters CS, Liang X, Li S, Kannan S, Peng Y, Taub R, Diamond RH (Apr 2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J Biol Chem. 276 (17): 13718–26. doi:10.1074/jbc.M011562200. PMID 11278933.
5. "Entrez Gene: ATF7 activating transcription factor 7".

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Hamard PJ, Dalbies-Tran R, Hauss C, Davidson I, Kedinger C, Chatton B (2005). "A functional interaction between ATF7 and TAF12 that is modulated by TAF4". Oncogene. 24 (21): 3472–83. doi:10.1038/sj.onc.1208565. PMID 15735663.
• Hamard PJ, Boyer-Guittaut M, Camuzeaux B, Dujardin D, Hauss C, Oelgeschläger T, Vigneron M, Kedinger C, Chatton B (2007). "Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity". Nucleic Acids Res. 35 (4): 1134–44. doi:10.1093/nar/gkl1168. PMC 1851647. PMID 17264123.
• Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N (2007). "Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells". Genes Dev. 21 (16): 2069–82. doi:10.1101/gad.430207. PMC 1948861. PMID 17699753.
• Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–101. doi:10.1126/science.1084648. PMID 12805554.
• Newman SP, Bates NP, Vernimmen D, Parker MG, Hurst HC (2000). "Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer". Oncogene. 19 (4): 490–7. doi:10.1038/sj.onc.1203416. PMID 10698518.
• Goetz J, Chatton B, Mattei MG, Kedinger C (1997). "Structure and expression of the ATFa gene". J. Biol. Chem. 271 (47): 29589–98. doi:10.1074/jbc.271.47.29589. PMID 8939888.
• Bocco JL, Bahr A, Goetz J, Hauss C, Kallunki T, Kedinger C, Chatton B (1996). "In vivo association of ATFa with JNK/SAP kinase activities". Oncogene. 12 (9): 1971–80. PMID 8649858.
• Pescini R, Kaszubska W, Whelan J, DeLamarter JF, Hooft van Huijsduijnen R (1994). "ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers". J. Biol. Chem. 269 (2): 1159–65. PMID 8288576.
• Zhou Q, Gedrich RW, Engel DA (1995). "Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB". J. Virol. 69 (7): 4323–30. PMC 189172. PMID 7769693.

External links

• ATF7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.