FOXH1

FOXH1
Identifiers
Aliases	FOXH1, FAST-1, FAST1, forkhead box H1
External IDs	MGI: 1347465 HomoloGene: 2914 GeneCards: FOXH1
Gene ontology Molecular function • co-SMAD binding • RNA polymerase II transcription cofactor activity • protein domain specific binding • sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • enhancer binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • androgen receptor binding • transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • bHLH transcription factor binding • DNA binding • transcriptional activator activity, RNA polymerase II transcription factor binding • protein binding • R-SMAD binding • SMAD binding Cellular component • nucleoplasm • activin responsive factor complex • nuclear chromatin • transcription factor complex • nucleus Biological process • ventricular trabecula myocardium morphogenesis • anterior/posterior pattern specification • negative regulation of androgen receptor signaling pathway • embryonic heart tube anterior/posterior pattern specification • transcription, DNA-templated • outflow tract morphogenesis • nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry • regulation of transcription from RNA polymerase II promoter • heart looping • negative regulation of androgen receptor activity • axial mesoderm development • cardiac right ventricle morphogenesis • negative regulation of transcription from RNA polymerase II promoter • determination of left/right symmetry • secondary heart field specification • positive regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • aorta morphogenesis • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • negative regulation of intracellular estrogen receptor signaling pathway • transforming growth factor beta receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8928	14106
Ensembl	ENSG00000160973	ENSMUSG00000033837
UniProt	O75593	O88621
RefSeq (mRNA)	NM_003923	NM_007989
RefSeq (protein)	NP_003914.1	NP_032015.1
Location (UCSC)	Chr 8: 144.47 – 144.48 Mb	Chr 15: 76.67 – 76.67 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Forkhead box protein H1 is a protein that in humans is encoded by the FOXH1 gene.^[3][4]

Function

FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT.^[4]

Interactions

FOXH1 has been shown to interact with DRAP1^[5] and Mothers against decapentaplegic homolog 2.^{[6][7][8][9][10]}

See also

• FOX proteins

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Zhou S, Zawel L, Lengauer C, Kinzler KW, Vogelstein B (August 1998). "Characterization of human FAST-1, a TGF beta and activin signal transducer". Mol Cell. 2 (1): 121–7. doi:10.1016/S1097-2765(00)80120-3. PMID 9702198.
4. "Entrez Gene: FOXH1 forkhead box H1".
5. Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM (December 2002). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260.
6. Wotton D, Lo RS, Lee S, Massagué J (April 1999). "A Smad transcriptional corepressor". Cell. 97 (1): 29–39. doi:10.1016/S0092-8674(00)80712-6. PMID 10199400.
7. Liu B, Dou CL, Prabhu L, Lai E (January 1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. 19 (1): 424–30. PMC 83900. PMID 9858566.
8. Liu F, Pouponnot C, Massagué J (December 1997). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. PMC 316747. PMID 9389648.
9. Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (September 2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097.
10. Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (September 1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature. 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972.

Further reading

• Chen X, Weisberg E, Fridmacher V, Watanabe M, Naco G, Whitman M (1997). "Smad4 and FAST-1 in the assembly of activin-responsive factor". Nature. 389 (6646): 85–9. doi:10.1038/38008. PMID 9288972.
• Liu F, Pouponnot C, Massagué J (1998). "Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes". Genes Dev. 11 (23): 3157–67. doi:10.1101/gad.11.23.3157. PMC 316747. PMID 9389648.
• Liu B, Dou CL, Prabhu L, Lai E (1999). "FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals". Mol. Cell. Biol. 19 (1): 424–30. PMC 83900. PMID 9858566.
• Dou C, Lee J, Liu B, Liu F, Massague J, Xuan S, Lai E (2000). "BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners". Mol. Cell. Biol. 20 (17): 6201–11. doi:10.1128/MCB.20.17.6201-6211.2000. PMC 86095. PMID 10938097.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Pessah M, Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, Gauthier JM, Atfi A (2001). "c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity". Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6198–203. doi:10.1073/pnas.101579798. PMC 33445. PMID 11371641.
• Iratni R, Yan YT, Chen C, Ding J, Zhang Y, Price SM, Reinberg D, Shen MM (2003). "Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1". Science. 298 (5600): 1996–9. doi:10.1126/science.1073405. PMID 12471260.
• Seoane J, Le HV, Shen L, Anderson SA, Massagué J (2004). "Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation". Cell. 117 (2): 211–23. doi:10.1016/S0092-8674(04)00298-3. PMID 15084259.
• von Both I, Silvestri C, Erdemir T, Lickert H, Walls JR, Henkelman RM, Rossant J, Harvey RP, Attisano L, Wrana JL (2004). "Foxh1 is essential for development of the anterior heart field". Dev. Cell. 7 (3): 331–45. doi:10.1016/j.devcel.2004.07.023. PMID 15363409.
• Kelemen SF, Eisen HJ, Autieri MV (2005). "Expression of the FAST-1 transcription factor in coronary artery transplant vasculopathy and activated vascular smooth muscle cells". J. Heart Lung Transplant. 24 (3): 246–50. doi:10.1016/j.healun.2004.01.015. PMID 15737749.
• Cui Q, Lim SK, Zhao B, Hoffmann FM (2005). "Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP". Oncogene. 24 (24): 3864–74. doi:10.1038/sj.onc.1208556. PMID 15750622.
• Hart AH, Willson TA, Wong M, Parker K, Robb L (2005). "Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1". Biochem. Biophys. Res. Commun. 333 (4): 1361–9. doi:10.1016/j.bbrc.2005.06.044. PMID 15982639.
• Chen G, Nomura M, Morinaga H, Matsubara E, Okabe T, Goto K, Yanase T, Zheng H, Lu J, Nawata H (2006). "Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor". J. Biol. Chem. 280 (43): 36355–63. doi:10.1074/jbc.M506147200. PMID 16120611.

External links

• FOXH1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.