ZNF365

ZNF365
Identifiers
Aliases	ZNF365, Su48, UAN, ZNF365D, zinc finger protein 365
External IDs	MGI: 2143676 HomoloGene: 8975 GeneCards: ZNF365
Genetically Related Diseases
narcolepsy, breast cancer, atopic dermatitis[1]
Gene ontology Molecular function • protein homodimerization activity • protein binding Cellular component • gamma-tubulin complex • centrosome • cytoplasm • cytoskeleton • microtubule organizing center Biological process • gamma-tubulin complex localization • mitotic cytokinesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	22891	216049
Ensembl	ENSG00000138311	ENSMUSG00000037855
UniProt	Q70YC4 Q70YC5	Q8BG89
RefSeq (mRNA)	NM_014951 NM_199450 NM_199451 NM_199452	NM_178679
RefSeq (protein)	NP_955524.3 NP_055766.2 NP_955522.1 NP_955523.1	NP_848794.1
Location (UCSC)	Chr 10: 62.37 – 62.67 Mb	Chr 10: 67.89 – 67.91 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Protein ZNF365 is a protein that in humans is encoded by the ZNF365 gene.^[4][5][6]

Model organisms

Model organisms have been used in the study of ZNF365 function. A conditional knockout mouse line called Zfp365^{tm1a(KOMP)Wtsi} was generated at the Wellcome Trust Sanger Institute.^[7] Male and female animals underwent a standardized phenotypic screen^[8] to determine the effects of deletion.^{[9][10][11][12]} Additional screens performed: - In-depth immunological phenotyping^[13] - in-depth bone and cartilage phenotyping^[14]

Zfp365 knockout mouse phenotype

Characteristic	Phenotype
All data available at.[8][13][14]
Peripheral blood leukocytes 6 Weeks	Normal
Haematology 6 Weeks	Abnormal
Insulin	Normal
Homozygous viability at P14	Normal
Homozygous Fertility	Normal
Body weight	Normal
Neurological assessment	Normal
Grip strength	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology 16 Weeks	Normal
Peripheral blood leukocytes 16 Weeks	Normal
Heart weight	Normal
Salmonella infection	Normal
Cytotoxic T Cell Function	Normal
Spleen Immunophenotyping	Normal
Mesenteric Lymph Node Immunophenotyping	Normal
Bone Marrow Immunophenotyping	Normal
Epidermal Immune Composition	Normal
Influenza Challenge	Normal

References

1. "Diseases that are genetically associated with ZNF365 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
5. Gianfrancesco F, Esposito T, Ombra MN, Forabosco P, Maninchedda G, Fattorini M, Casula S, Vaccargiu S, Casu G, Cardia F, Deiana I, Melis P, Falchi M, Pirastu M (Jun 2003). "Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate". American Journal of Human Genetics. 72 (6): 1479–91. doi:10.1086/375628. PMC 1180308. PMID 12740763.
6. "Entrez Gene: ZNF365 zinc finger protein 365".
7. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
8. "International Mouse Phenotyping Consortium".
9. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
10. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
11. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
12. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (Jul 2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
13. "Infection and Immunity Immunophenotyping (3i) Consortium".
14. "OBCD Consortium".

Further reading

• Ombra MN, Forabosco P, Casula S, Angius A, Maestrale G, Petretto E, Casu G, Colussi G, Usai E, Melis P, Pirastu M (May 2001). "Identification of a new candidate locus for uric acid nephrolithiasis". American Journal of Human Genetics. 68 (5): 1119–29. doi:10.1086/320105. PMC 1226093. PMID 11309680.
• Gianfrancesco F, Esposito T, Casu G, Maninchedda G, Roberto R, Pirastu M (Sep 2004). "Emergence of Talanin protein associated with human uric acid nephrolithiasis in the Hominidae lineage". Gene. 339: 131–8. doi:10.1016/j.gene.2004.06.030. PMID 15363853.
• Wang Q, Du X, Meinkoth J, Hirohashi Y, Zhang H, Liu Q, Richter M, Greene MI (Apr 2006). "Characterization of Su48, a centrosome protein essential for cell division". Proceedings of the National Academy of Sciences of the United States of America. 103 (17): 6512–7. doi:10.1073/pnas.0601682103. PMC 1458915. PMID 16617106.
• Hirohashi Y, Wang Q, Liu Q, Li B, Du X, Zhang H, Furuuchi K, Masuda K, Sato N, Greene MI (Oct 2006). "Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation". Oncogene. 25 (45): 6048–55. doi:10.1038/sj.onc.1209637. PMID 16682949.

External links

• ZNF365 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.