ZNF41

ZNF41
Identifiers
Aliases	ZNF41, MRX89, zinc finger protein 41
External IDs	HomoloGene: 133263 GeneCards: ZNF41
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • DNA binding • protein binding • metal ion binding • nucleic acid binding Cellular component • intracellular • nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7592	n/a
Ensembl	ENSG00000147124	n/a
UniProt	P51814	n/a
RefSeq (mRNA)	NM_007130 NM_153380 NM_001324139 NM_001324140 NM_001324141 NM_001324142 NM_001324143 NM_001324144 NM_001324145 NM_001324147 NM_001324148 NM_001324149 NM_001324150 NM_001324151 NM_001324152 NM_001324153 NM_001324154 NM_001324155 NM_001324156 NM_001324157	n/a
RefSeq (protein)	NP_009061.1 NP_700359.1 NP_001311068.1 NP_001311069.1 NP_001311070.1 NP_001311071.1 NP_001311072.1 NP_001311073.1 NP_001311074.1 NP_001311076.1 NP_001311077.1 NP_001311078.1 NP_001311079.1 NP_001311080.1 NP_001311081.1 NP_001311082.1 NP_001311083.1 NP_001311084.1 NP_001311085.1 NP_001311086.1	n/a
Location (UCSC)	Chr X: 47.45 – 47.48 Mb	n/a
PubMed search	[1]	n/a
Wikidata

View/Edit Human

Zinc finger protein 41 is a protein that in humans is encoded by the ZNF41 gene.^[2][3]

This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. Several alternatively spliced transcript variants have been described, however, the full-length nature of only some of them is known.^[3]

References

1. "Human PubMed Reference:".
2. Franze A, Archidiacono N, Rocchi M, Marino M, Grimaldi G (Jul 1991). "Isolation and expression analysis of a human zinc finger gene (ZNF41) located on the short arm of the X chromosome". Genomics. 9 (4): 728–36. doi:10.1016/0888-7543(91)90367-N. PMID 2037297.
3. "Entrez Gene: ZNF41 zinc finger protein 41".

Further reading

• Rosati M, Marino M, Franzè A, et al. (1991). "Members of the zinc finger protein gene family sharing a conserved N-terminal module". Nucleic Acids Res. 19 (20): 5661–7. doi:10.1093/nar/19.20.5661. PMC 328972. PMID 1945843.
• Knight JC, Grimaldi G, Thiesen HJ, et al. (1994). "Clustered organization of Krüppel zinc-finger genes at Xp11.23, flanking a translocation breakpoint at OATL1: a physical map with locus assignments for ZNF21, ZNF41, ZNF81, and ELK1". Genomics. 21 (1): 180–7. doi:10.1006/geno.1994.1240. PMID 8088786.
• Rosati M, Franzé A, Matarazzo MR, Grimaldi G (1999). "Coding region intron/exon organization, alternative splicing, and X-chromosome inactivation of the KRAB/FPB-domain-containing human zinc finger gene ZNF41". Cytogenet. Cell Genet. 85 (3–4): 291–6. doi:10.1159/000015315. PMID 10449920.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shoichet SA, Hoffmann K, Menzel C, et al. (2004). "Mutations in the ZNF41 gene are associated with cognitive deficits: identification of a new candidate for X-linked mental retardation". Am. J. Hum. Genet. 73 (6): 1341–54. doi:10.1086/380309. PMC 1180399. PMID 14628291.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.

External links

• ZNF41 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.