NKX3-2

NKX3-2
Identifiers
Aliases	NKX3-2, NK3 homeobox 2, BAPX1, NKX3.2, NKX3B, SMMD
External IDs	MGI: 108015 HomoloGene: 68168 GeneCards: NKX3-2
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Cellular component • nucleus Biological process • animal organ development • skeletal system development • regulation of transcription, DNA-templated • digestive system development • intestinal epithelial cell development • skeletal system morphogenesis • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • spleen development • transcription from RNA polymerase II promoter • transcription, DNA-templated • embryonic skeletal system development • animal organ formation • determination of left/right symmetry • negative regulation of chondrocyte differentiation • middle ear morphogenesis • pancreas development Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	579	12020
Ensembl	ENSG00000109705	ENSMUSG00000049691
UniProt	P78367	P97503
RefSeq (mRNA)	NM_001189	NM_007524
RefSeq (protein)	NP_001180.1	NP_031550.2
Location (UCSC)	Chr 4: 13.54 – 13.55 Mb	Chr 5: 41.76 – 41.76 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe(bap) in Drosophila and therefore also known as Bapx1 (bagpipe homeobox homolog 1) . The protein encoded by this gene is a homeo domain containing transcription factor.^[3]

Function

NKX3-2 plays a role in the development of the skeleton.^[4] Nkx3-2 in mice also regulates patterning in the middle ear.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Yoshiura KI, Murray JC (October 1997). "Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia". Genomics. 45 (2): 425–8. doi:10.1006/geno.1997.4926. PMID 9344671.
4. Lettice L, Hecksher-Sørensen J, Hill R (2001). "The role of Bapx1 (Nkx3.2) in the development and evolution of the axial skeleton". J. Anat. 199 (Pt 1–2): 181–7. doi:10.1111/j.1469-7580.2008.00944.x. PMC 1594973. PMID 11523821.
5. Tucker AS, Watson RP, Lettice LA, Yamada G, Hill RE (2004). "Bapx1 regulates patterning in the middle ear: altered regulatory role in the transition from the proximal jaw during vertebrate evolution". Development. 131 (6): 1235–1245. doi:10.1242/dev.01017. PMID 14973294.

External links

• Bapx1 protein, mouse at the US National Library of Medicine Medical Subject Headings (MeSH)