MEOX2

MEOX2
Identifiers
Aliases MEOX2, GAX, MOX2, mesenchyme homeobox 2
External IDs MGI: 103219 HomoloGene: 4330 GeneCards: MEOX2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

4223

17286

Ensembl

ENSG00000106511

ENSMUSG00000036144

UniProt

P50222

P32443

RefSeq (mRNA)

NM_005924

NM_008584

RefSeq (protein)

NP_005915.2

NP_032610.1

Location (UCSC) Chr 7: 15.61 – 15.69 Mb Chr 12: 37.11 – 37.18 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Homeobox protein MOX-2 is a protein that in humans is encoded by the MEOX2 gene.[3][4]

Function

This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[4]

Interactions

MEOX2 has been shown to interact with PAX1[5] and PAX3.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. LePage DF, Altomare DA, Testa JR, Walsh K (May 1995). "Molecular cloning and localization of the human GAX gene to 7p21". Genomics. 24 (3): 535–40. doi:10.1006/geno.1994.1663. PMID 7713505.
  4. 1 2 "Entrez Gene: MEOX2 mesenchyme homeobox 2".
  5. 1 2 Stamataki D, Kastrinaki M, Mankoo BS, Pachnis V, Karagogeos D (Jun 2001). "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Lett. 499 (3): 274–8. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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