HOXA3

HOXA3
Identifiers
Aliases	HOXA3, HOX1, HOX1E, homeobox A3
External IDs	MGI: 96175 HomoloGene: 40725 GeneCards: HOXA3
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • HMG box domain binding • protein binding Cellular component • nucleoplasm • nucleus Biological process • embryonic skeletal system morphogenesis • glossopharyngeal nerve morphogenesis • regulation of transcription, DNA-templated • thymus development • transcription, DNA-templated • embryonic skeletal system development • multicellular organism development • animal organ formation • blood vessel remodeling • thyroid gland development • cartilage development • parathyroid gland development • angiogenesis • positive regulation of cell proliferation • animal organ morphogenesis • specification of animal organ position • anterior/posterior pattern specification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3200	15400
Ensembl	ENSG00000105997	ENSMUSG00000079560
UniProt	O43365	P02831
RefSeq (mRNA)	NM_030661 NM_153631 NM_153632	NM_010452
RefSeq (protein)	NP_109377.1 NP_705895.1	NP_034582.1
Location (UCSC)	Chr 7: 27.11 – 27.15 Mb	Chr 6: 52.17 – 52.21 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Homeobox protein Hox-A3 is a protein that in humans is encoded by the HOXA3 gene.^[3][4][5]

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.^[5]

Regulation

The HOXA3 gene is repressed by the microRNA miR-10a.^[6]

See also

• Homeobox

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. McAlpine PJ, Shows TB (July 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
4. Scott MP (November 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
5. "Entrez Gene: HOXA3 homeobox A3".
6. Han L, Witmer PD, Casey E, Valle D, Sukumar S (August 2007). "DNA methylation regulates MicroRNA expression". Cancer Biology & Therapy. 6 (8): 1284–8. PMID 17660710.

Further reading

• Apiou F, Flagiello D, Cillo C, Malfoy B, Poupon MF, Dutrillaux B (1996). "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics. 73 (1-2): 114–5. doi:10.1159/000134320. PMID 8646877.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Manley NR, Capecchi MR (March 1998). "Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands". Developmental Biology. 195 (1): 1–15. doi:10.1006/dbio.1997.8827. PMID 9520319.
• "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. November 1998. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Mulder GB, Manley N, Maggio-Price L (December 1998). "Retinoic acid-induced thymic abnormalities in the mouse are associated with altered pharyngeal morphology, thymocyte maturation defects, and altered expression of Hoxa3 and Pax1". Teratology. 58 (6): 263–75. doi:10.1002/(SICI)1096-9926(199812)58:6<263::AID-TERA8>3.0.CO;2-A. PMID 9894676.
• Manzanares M, Nardelli J, Gilardi-Hebenstreit P, Marshall H, Giudicelli F, Martínez-Pastor MT, Krumlauf R, Charnay P (February 2002). "Krox20 and kreisler co-operate in the transcriptional control of segmental expression of Hoxb3 in the developing hindbrain". The EMBO Journal. 21 (3): 365–76. doi:10.1093/emboj/21.3.365. PMC 125344. PMID 11823429.
• Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (February 2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology. 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
• Kim J, Bhinge AA, Morgan XC, Iyer VR (January 2005). "Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment". Nature Methods. 2 (1): 47–53. doi:10.1038/nmeth726. PMID 15782160.
• Wissmüller S, Kosian T, Wolf M, Finzsch M, Wegner M (2006). "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Research. 34 (6): 1735–44. doi:10.1093/nar/gkl105. PMC 1421504. PMID 16582099.

External links

• HOXA3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.