Neuron-derived orphan receptor 1

NR4A3
Identifiers
Aliases	NR4A3, CHN, CSMF, MINOR, NOR1, TEC, nuclear receptor subfamily 4 group A member 3
External IDs	OMIM: 600542 MGI: 1352457 HomoloGene: 5074 GeneCards: NR4A3
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • protein homodimerization activity • transcription factor activity, sequence-specific DNA binding • zinc ion binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • steroid hormone receptor activity • RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding • core promoter sequence-specific DNA binding • thyroid hormone receptor activity • protein binding • histone acetyltransferase binding • glucocorticoid receptor binding • transcription coactivator binding • protein kinase binding Cellular component • transcription factor complex • mast cell granule • nucleoplasm • nucleus Biological process • negative regulation of neuron apoptotic process • cellular response to catecholamine stimulus • semicircular canal morphogenesis • regulation of transcription, DNA-templated • biological process • neuromuscular process controlling balance • positive regulation of epithelial cell proliferation • common myeloid progenitor cell proliferation • pyruvate oxidation • negative regulation of oxidative stress-induced neuron death • mesoderm formation • response to peptide hormone • negative regulation of apoptotic process • positive regulation of leukocyte apoptotic process • negative regulation of transcription from RNA polymerase II promoter • regulation of smooth muscle cell proliferation • cellular response to leptin stimulus • transcription, DNA-templated • positive regulation of cardiac muscle hypertrophy • axon guidance • positive regulation of transcription, DNA-templated • adult behavior • positive regulation of cell cycle • negative regulation of hydrogen peroxide-induced neuron death • gastrulation • positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway • animal organ regeneration • inner ear morphogenesis • positive regulation of mast cell cytokine production • cellular respiration • vestibular reflex • energy homeostasis • cellular response to corticotropin-releasing hormone stimulus • mast cell degranulation • transcription initiation from RNA polymerase II promoter • positive regulation of feeding behavior • positive regulation of glucose transport • hippocampus development • positive regulation of monocyte aggregation • fat cell differentiation • response to hydrogen peroxide • regulation of type B pancreatic cell proliferation • positive regulation of transcription from RNA polymerase II promoter • steroid hormone mediated signaling pathway • positive regulation of smooth muscle cell proliferation • positive regulation of fatty acid oxidation • regulation of energy homeostasis • intracellular receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8013	18124
Ensembl	ENSG00000119508	ENSMUSG00000028341
UniProt	Q92570	Q9QZB6
RefSeq (mRNA)	NM_006981 NM_173198 NM_173199 NM_173200	NM_015743 NM_001307989
RefSeq (protein)	NP_008912.2 NP_775291.1 NP_775292.1	NP_001294918.1 NP_056558.1
Location (UCSC)	Chr 9: 99.82 – 99.87 Mb	Chr 4: 48.05 – 48.09 Mb
PubMed search	[1]	[2]
Wikidata

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The neuron-derived orphan receptor 1 (NOR1) also known as NR4A3 (nuclear receptor subfamily 4, group A, member 3) is a protein that in humans is encoded by the NR4A3 gene.^[3] NOR1 is a member of the nuclear receptor family of intracellular transcription factors.

NOR1 plays a central regulatory role in cell proliferation, differentiation, metabolism^[4][5] and apoptosis^[6]

Interactions

Neuron-derived orphan receptor 1 has been shown to interact with SIX3.^[7][8]

See also

• NUR nuclear receptor family

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Hedvat CV, Irving SG (Dec 1995). "The isolation and characterization of MINOR, a novel mitogen-inducible nuclear orphan receptor". Molecular Endocrinology. 9 (12): 1692–700. doi:10.1210/me.9.12.1692. PMID 8614405.
4. Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (Nov 2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology. 147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID 16901967.
5. Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (Jun 2008). "The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle". Endocrinology. 149 (6): 2853–65. doi:10.1210/en.2007-1202. PMID 18325999.
6. Nomiyama T, Nakamachi T, Gizard F, Heywood EB, Jones KL, Ohkura N, Kawamori R, Conneely OM, Bruemmer D (Nov 2006). "The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates vascular smooth muscle cell proliferation". The Journal of Biological Chemistry. 281 (44): 33467–76. doi:10.1074/jbc.M603436200. PMC 1829169. PMID 16945922.
7. Laflamme C, Filion C, Bridge JA, Ladanyi M, Goldring MB, Labelle Y (Jan 2003). "The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in human extraskeletal myxoid chondrosarcomas". Cancer Research. 63 (2): 449–54. PMID 12543801.
8. Ohkura N, Ohkubo T, Maruyama K, Tsukada T, Yamaguchi K (2001). "The orphan nuclear receptor NOR-1 interacts with the homeobox containing protein Six3". Developmental Neuroscience. 23 (1): 17–24. doi:10.1159/000048692. PMID 11173923.

Further reading

• Ohkura N, Hijikuro M, Yamamoto A, Miki K (Dec 1994). "Molecular cloning of a novel thyroid/steroid receptor superfamily gene from cultured rat neuronal cells". Biochemical and Biophysical Research Communications. 205 (3): 1959–65. doi:10.1006/bbrc.1994.2900. PMID 7811288.
• Clark J, Benjamin H, Gill S, Sidhar S, Goodwin G, Crew J, Gusterson BA, Shipley J, Cooper CS (Jan 1996). "Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma". Oncogene. 12 (2): 229–35. PMID 8570200.
• Labelle Y, Zucman J, Stenman G, Kindblom LG, Knight J, Turc-Carel C, Dockhorn-Dworniczak B, Mandahl N, Desmaze C, Peter M (Dec 1995). "Oncogenic conversion of a novel orphan nuclear receptor by chromosome translocation". Human Molecular Genetics. 4 (12): 2219–26. doi:10.1093/hmg/4.12.2219. PMID 8634690.
• Ohkura N, Ito M, Tsukada T, Sasaki K, Yamaguchi K, Miki K (Sep 1996). "Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family". Biochimica et Biophysica Acta. 1308 (3): 205–14. doi:10.1016/0167-4781(96)00101-7. PMID 8809112.
• Ohkura N, Ito M, Tsukada T, Sasaki K, Yamaguchi K, Miki K (Apr 1998). "Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA". Gene. 211 (1): 79–85. doi:10.1016/S0378-1119(98)00095-X. PMID 9573341.
• Labelle Y, Bussières J, Courjal F, Goldring MB (May 1999). "The EWS/TEC fusion protein encoded by the t(9;22) chromosomal translocation in human chondrosarcomas is a highly potent transcriptional activator". Oncogene. 18 (21): 3303–8. doi:10.1038/sj.onc.1202675. PMID 10359536.
• Panagopoulos I, Mencinger M, Dietrich CU, Bjerkehagen B, Saeter G, Mertens F, Mandahl N, Heim S (Dec 1999). "Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11)". Oncogene. 18 (52): 7594–8. doi:10.1038/sj.onc.1203155. PMID 10602519.
• Sjögren H, Wedell B, Meis-Kindblom JM, Kindblom LG, Stenman G, Kindblom JM (Dec 2000). "Fusion of the NH2-terminal domain of the basic helix-loop-helix protein TCF12 to TEC in extraskeletal myxoid chondrosarcoma with translocation t(9;15)(q22;q21)". Cancer Research. 60 (24): 6832–5. PMID 11156374.
• Liu D, Jia H, Holmes DI, Stannard A, Zachary I (Nov 2003). "Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1". Arteriosclerosis, Thrombosis, and Vascular Biology. 23 (11): 2002–7. doi:10.1161/01.ATV.0000098644.03153.6F. PMID 14525795.
• Rius J, Martínez-González J, Crespo J, Badimon L (Apr 2004). "Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB". Arteriosclerosis, Thrombosis, and Vascular Biology. 24 (4): 697–702. doi:10.1161/01.ATV.0000121570.00515.dc. PMID 14962944.
• Hisaoka M, Okamoto S, Yokoyama K, Hashimoto H (Jul 2004). "Coexpression of NOR1 and SIX3 proteins in extraskeletal myxoid chondrosarcomas without detectable NR4A3 fusion genes". Cancer Genetics and Cytogenetics. 152 (2): 101–7. doi:10.1016/j.cancergencyto.2003.11.011. PMID 15262426.
• Laflamme C, Filion C, Labelle Y (Dec 2004). "Functional characterization of SIX3 homeodomain mutations in holoprosencephaly: interaction with the nuclear receptor NR4A3/NOR1". Human Mutation. 24 (6): 502–8. doi:10.1002/humu.20102. PMID 15523651.
• Rius J, Martínez-González J, Crespo J, Badimon L (Feb 2006). "NOR-1 is involved in VEGF-induced endothelial cell growth". Atherosclerosis. 184 (2): 276–82. doi:10.1016/j.atherosclerosis.2005.04.008. PMID 15949808.
• Pei L, Castrillo A, Chen M, Hoffmann A, Tontonoz P (Aug 2005). "Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli". The Journal of Biological Chemistry. 280 (32): 29256–62. doi:10.1074/jbc.M502606200. PMID 15964844.
• Bonta PI, van Tiel CM, Vos M, Pols TW, van Thienen JV, Ferreira V, Arkenbout EK, Seppen J, Spek CA, van der Poll T, Pannekoek H, de Vries CJ (Oct 2006). "Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses". Arteriosclerosis, Thrombosis, and Vascular Biology. 26 (10): 2288–94. doi:10.1161/01.ATV.0000238346.84458.5d. PMID 16873729.
• Pearen MA, Ryall JG, Maxwell MA, Ohkura N, Lynch GS, Muscat GE (Nov 2006). "The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle". Endocrinology. 147 (11): 5217–27. doi:10.1210/en.2006-0447. PMID 16901967.
• Pearen MA, Myers SA, Raichur S, Ryall JG, Lynch GS, Muscat GE (Jun 2008). "The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle". Endocrinology. 149 (6): 2853–65. doi:10.1210/en.2007-1202. PMID 18325999.
• Vacca M, Murzilli S, Salvatore L, Di Tullio G, D'Orazio A, Lo Sasso G, Graziano G, Pinzani M, Chieppa M, Mariani-Costantini R, Palasciano G, Moschetta A (Jun 2013). "Neuron-derived orphan receptor 1 promotes proliferation of quiescent hepatocytes". Gastroenterology. 144 (7): 1518–1529.e3. doi:10.1053/j.gastro.2013.02.027. PMID 23462179.

External links

• NR4A3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)