ZNF43

ZNF43
Identifiers
Aliases	ZNF43, HTF6, KOX27, ZNF39L1, zinc finger protein 43
External IDs	MGI: 3040691 HomoloGene: 128170 GeneCards: ZNF43
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • DNA binding • metal ion binding • nucleic acid binding Cellular component • intracellular • nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7594	238690
Ensembl	n/a	ENSMUSG00000055480
UniProt	P17038	Q6P5C7
RefSeq (mRNA)	NM_001256648 NM_001256649 NM_001256650 NM_001256651 NM_001256653 NM_001256654 NM_003423	NM_001001152
RefSeq (protein)	NP_001243577.1 NP_001243578.1 NP_001243579.1 NP_003414.2 NP_001243577.1 NP_001243578.1 NP_001243579.1	NP_001001152.1
Location (UCSC)	Chr 19: 21.8 – 21.85 Mb	Chr 13: 67.25 – 67.27 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Zinc finger protein 43 is a protein that in humans is encoded by the ZNF43 gene.^[3][4]

Function

This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions.^[4]

See also

• Zinc finger

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Lovering R, Trowsdale J (Jun 1991). "A gene encoding 22 highly related zinc fingers is expressed in lymphoid cell lines". Nucleic Acids Research. 19 (11): 2921–8. doi:10.1093/nar/19.11.2921. PMC 328252. PMID 1711675.
4. "Entrez Gene: ZNF43 zinc finger protein 43".

Further reading

• Huebner K, Druck T, Croce CM, Thiesen HJ (Apr 1991). "Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering". American Journal of Human Genetics. 48 (4): 726–40. PMC 1682948. PMID 2014798.
• Bellefroid EJ, Poncelet DA, Lecocq PJ, Revelant O, Martial JA (May 1991). "The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins". Proceedings of the National Academy of Sciences of the United States of America. 88 (9): 3608–12. doi:10.1073/pnas.88.9.3608. PMC 51501. PMID 2023909.
• Thiesen HJ (Apr 1990). "Multiple genes encoding zinc finger domains are expressed in human T cells". The New Biologist. 2 (4): 363–74. PMID 2288909.
• Bellefroid EJ, Marine JC, Ried T, Lecocq PJ, Rivière M, Amemiya C, Poncelet DA, Coulie PG, de Jong P, Szpirer C (Apr 1993). "Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells". The EMBO Journal. 12 (4): 1363–74. PMC 413348. PMID 8467795.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Takahashi T, Furuchi T, Naganuma A (Dec 2006). "Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells". Cancer Research. 66 (24): 11932–7. doi:10.1158/0008-5472.CAN-06-3220. PMID 17178891.

External links

• ZNF43 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.