NFIB (gene)

NFIB
Identifiers
Aliases	NFIB, CTF, HMGIC/NF-I/B, NF1-B, NFI-B, NFI-RED, NFIB2, NFIB3, nuclear factor I B
External IDs	MGI: 103188 HomoloGene: 4087 GeneCards: NFIB
Gene ontology Molecular function • DNA binding • RNA polymerase II transcription corepressor activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • double-stranded DNA binding Cellular component • intracellular • cerebellar mossy fiber • nucleolus • nucleus Biological process • cell differentiation involved in salivary gland development • Clara cell differentiation • negative regulation of epithelial cell proliferation involved in lung morphogenesis • regulation of transcription, DNA-templated • negative regulation of mesenchymal cell proliferation involved in lung development • chondrocyte differentiation • lung development • negative regulation of DNA binding • salivary gland cavitation • hindbrain development • glial cell differentiation • negative regulation of transcription from RNA polymerase II promoter • commissural neuron axon guidance • transcription, DNA-templated • anterior commissure morphogenesis • lung ciliated cell differentiation • DNA replication • Type I pneumocyte differentiation • principal sensory nucleus of trigeminal nerve development • forebrain development • Type II pneumocyte differentiation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of pri-miRNA transcription from RNA polymerase II promoter • negative regulation of cell proliferation • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4781	18028
Ensembl	ENSG00000147862	ENSMUSG00000008575
UniProt	O00712	P97863
RefSeq (mRNA)	NM_001190737 NM_001190738 NM_001282787 NM_005596	NM_001113209 NM_001113210 NM_001286127 NM_001286131 NM_008687
RefSeq (protein)	NP_001177666.1 NP_001177667.1 NP_001269716.1 NP_005587.2	NP_001106680.1 NP_032713.3
Location (UCSC)	Chr 9: 14.08 – 14.4 Mb	Chr 4: 82.29 – 82.71 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Nuclear factor 1 B-type is a protein that in humans is encoded by the NFIB gene.^[3][4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Qian F, Kruse U, Lichter P, Sippel AE (Dec 1995). "Chromosomal localization of the four genes (NFIA, B, C, and X) for the human transcription factor nuclear factor I by FISH". Genomics. 28 (1): 66–73. doi:10.1006/geno.1995.1107. PMID 7590749.
4. "Entrez Gene: NFIB nuclear factor I/B".

Further reading

• Liu Y, Bernard HU, Apt D (1997). "NFI-B3, a novel transcriptional repressor of the nuclear factor I family, is generated by alternative RNA processing.". J. Biol. Chem. 272 (16): 10739–45. doi:10.1074/jbc.272.16.10739. PMID 9099724.
• Geurts JM, Schoenmakers EF, Röijer E, et al. (1998). "Identification of NFIB as recurrent translocation partner gene of HMGIC in pleomorphic adenomas". Oncogene. 16 (7): 865–72. doi:10.1038/sj.onc.1201609. PMID 9484777.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Norquay LD, Yang X, Sheppard P, et al. (2003). "RFX1 and NF-1 associate with P sequences of the human growth hormone locus in pituitary chromatin". Mol. Endocrinol. 17 (6): 1027–38. doi:10.1210/me.2003-0025. PMID 12624117.
• Sheeter D, Du P, Rought S, et al. (2003). "Surface CD4 expression modulated by a cellular factor induced by HIV type 1 infection". AIDS Res. Hum. Retroviruses. 19 (2): 117–23. doi:10.1089/088922203762688621. PMID 12639247.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mukhopadhyay SS, Rosen JM (2007). "The C-terminal domain of the Nuclear Factor I-B2 isoform is glycosylated and transactivates the WAP gene in the JEG-3 cells". Biochem. Biophys. Res. Commun. 358 (3): 770–6. doi:10.1016/j.bbrc.2007.04.185. PMC 1942171. PMID 17511965.

External links

• NFIB protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.