TSHZ3

TSHZ3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DMI
Identifiers
Aliases	TSHZ3, TSH3, ZNF537, teashirt zinc finger homeobox 3
External IDs	MGI: 2442819 HomoloGene: 10835 GeneCards: TSHZ3
Gene ontology Molecular function • metal ion binding • DNA binding • chromatin binding • protein binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Cellular component • cell projection • growth cone • nucleus • nucleoplasm Biological process • regulation of gene expression • regulation of transcription, DNA-templated • transcription, DNA-templated • regulation of respiratory gaseous exchange by neurological system process • negative regulation of transcription, DNA-templated • multicellular organism development • regulation of transcription from RNA polymerase II promoter • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57616	243931
Ensembl	ENSG00000121297	ENSMUSG00000021217
UniProt	Q63HK5	Q8CGV9
RefSeq (mRNA)	NM_020856	NM_172298
RefSeq (protein)	NP_065907.2	NP_758502.1
Location (UCSC)	Chr 19: 31.27 – 31.35 Mb	Chr 7: 36.7 – 36.77 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Teashirt homolog 3 is a protein that in humans is encoded by the TSHZ3 gene.^[3] In mice, it is a necessary part of the neural circuitry that controls breathing. The gene is also a homolog of the Drosophila melanogaster teashirt gene, which encodes a zinc finger transcription factor important for development of the trunk.

Tshz3-knockout mice do not develop the respiratory rhythm generator (RRG) neural circuit, which is a pacemaker that produces an oscillating rhythm in the brainstem and controls autonomous breathing. The RRG neurons are present, but are abnormal. Those mice do not survive because they don't initiate breathing after birth. Tshz-3 is being studied for its relationship to infant breathing defects in humans.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: TSHZ3 teashirt family zinc finger 3".
4. Caubit X, Thoby-Brisson M, Voituron N, Filippi P, Bévengut M, Faralli H, Zanella S, Fortin G, Hilaire G, Fasano L (July 2010). "Teashirt 3 regulates development of neurons involved in both respiratory rhythm and airflow control". J. Neurosci. 30 (28): 9465–76. doi:10.1523/JNEUROSCI.1765-10.2010. PMID 20631175. Lay summary – New Scientist.

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.