HIVEP3

HIVEP3
Identifiers
Aliases	HIVEP3, Hivep3, 2900056N03Rik, A130075N07, AI848000, E030045D18Rik, KBP-1, KBP1, Krc, Rc, Schnurri-3, Shn3, Zas3, ZNF40C, human immunodeficiency virus type I enhancer binding protein 3
External IDs	MGI: 106589 HomoloGene: 7803 GeneCards: HIVEP3
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcription regulatory region DNA binding • sequence-specific DNA binding • DNA binding • metal ion binding • nucleic acid binding Cellular component • cytoplasm • nucleus Biological process • multicellular organism development • skeletal muscle cell differentiation • positive regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • signal transduction • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	59269	16656
Ensembl	ENSG00000127124	ENSMUSG00000028634
UniProt	Q5T1R4	A2A884
RefSeq (mRNA)	NM_001127714 NM_024503	NM_010657
RefSeq (protein)	NP_001121186.1 NP_078779.2	NP_034787.2
Location (UCSC)	Chr 1: 41.51 – 42.04 Mb	Chr 4: 119.73 – 120.14 Mb
PubMed search	[1]	[2]
Wikidata

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Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.^[3][4]

Function

Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM]^[4]

It regulates osteoblasts.^[5]

Interactions

HIVEP3 has been shown to interact with TRAF1^[6] and TRAF2.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Hicar MD, Liu Y, Allen CE, Wu LC (Jan 2001). "Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2". Genomics. 71 (1): 89–100. doi:10.1006/geno.2000.6425. PMID 11161801.
4. "Entrez Gene: HIVEP3 human immunodeficiency virus type I enhancer binding protein 3".
5. Glimcher, LH; Jones, DC; Wein, MN (November 2007). "Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3.". Annals of the New York Academy of Sciences. 1116: 174–81. PMID 18083927.
6. Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH (Jan 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Molecular Cell. 9 (1): 121–31. doi:10.1016/S1097-2765(01)00434-8. PMID 11804591.

Further reading

• Rustgi AK, Van 't Veer LJ, Bernards R (Nov 1990). "Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties". Proceedings of the National Academy of Sciences of the United States of America. 87 (22): 8707–10. doi:10.1073/pnas.87.22.8707. PMC 55028. PMID 2247438.
• Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Aug 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH (Jan 2002). "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Molecular Cell. 9 (1): 121–31. doi:10.1016/S1097-2765(01)00434-8. PMID 11804591.
• Oukka M, Wein MN, Glimcher LH (Jan 2004). "Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells". The Journal of Experimental Medicine. 199 (1): 15–24. doi:10.1084/jem.20030421. PMC 1887724. PMID 14707112.
• Qin H, Wang J, Liang Y, Taniguchi Y, Tanigaki K, Han H (2004). "RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2". Nucleic Acids Research. 32 (4): 1492–501. doi:10.1093/nar/gkh295. PMC 390284. PMID 14999091.
• Hong JW, Wu LC (Jan 2005). "Structural characterization of the gene encoding the large zinc finger protein ZAS3: implication to the origin of multiple promoters in eukaryotic genes". Biochimica et Biophysica Acta. 1681 (2-3): 74–87. doi:10.1016/j.bbaexp.2004.10.004. PMID 15627499.
• Bettelli E, Dastrange M, Oukka M (Apr 2005). "Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells". Proceedings of the National Academy of Sciences of the United States of America. 102 (14): 5138–43. doi:10.1073/pnas.0501675102. PMC 555574. PMID 15790681.
• Li YJ, Deng J, Mayhew GM, Grimsley JW, Huo X, Vance JM (Sep 2007). "Investigation of the PARK10 gene in Parkinson disease". Annals of Human Genetics. 71 (Pt 5): 639–47. doi:10.1111/j.1469-1809.2007.00353.x. PMID 17388942.

External links

• HIVEP3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.